Fantasy Premier League (FPL) managers will be anxiously watching Bruno Fernandes (£11.4m) who has been captained by a record 2,715,840, the highest amount ever recorded.
Mason Greenwood (£7.0m) and Marcus Rashford (£9.6m) start out wide with Anthony Martial (£8.8m) playing through the middle.
Paul Pogba (£7.7m) continues in a central midfield role for the Red Devils, alongside Nemanja Matic (£4.7m).
Arron Wan-Bissaka (£5.4m) and Alex Telles (£5.5m) start at full-back, with Harry Maguire (£5.4m) and Axel Tuanzebe (£4.2m) at centre-half. David De Gea (£5.3m) remains in goal.
David McGoldrick (£5.2m) will be hoping to add Manchester United to his big six scalps this season.
Club legend Billy Sharp (£5.5m) starts up front with McGoldrick.
The Blades midfield has a familiar look, with John Lundstram (£4.9m), John Fleck (£5.6m) and Oliver Norwood (£4.6m) in central midfield. Kean Bryan (£3.9m) and George Baldock (£4.9m) start at wing-back.
Phil Jagielka (£3.9m), Chris Basham (£4.6m) and Ethan Ampadu (£4.3m) start at centre-back, with Aaron Ramsdale (£4.6m) in goal.
Dominic Calvert-Lewin (£7.6m) will be hoping to fire himself back into form after breaking his goal drought in the FA Cup.
James Rodriguez (£7.7m) and Richarlison (£7.8m) join DCL. Tom Davies and Andre Gomes (£5.3m) line-up in midfield.
Lucas Digne (£6.0m) and Mason Holgate (£4.8m) start in defence, with Yerry Mina (£5.6m) and Michael Keane (£5.1m) and Ben Godfrey (£5.0m). Jordan Pickford (£4.8m) continues in goal.
Ayoze Perez (£6.0m) continues in a false nine role for Leicester in the absence of Jamie Vardy (£10.0m).
James Maddison (£7.2m), Harvey Barnes (£6.8m) and Marc Albrighton (£5.3m) line-up behind Perez.
Youri Tielemans (£6.4m) and Wilfred Ndidi (£4.8m) start in the heart of the Leicester midfield.
James Justin (£5.0m) and Timothy Castagne (£5.7m) line-up at full-back, with Wesley Fofana (£5.0m) and Jonny Evans (£5.5m) at centre-back. Kasper Schmeichel (£5.5m) plays in goal.
Neal Maupay (£6.1m) leads the line for Brighton tonight in a six-pointer at the bottom of the table.
Supporting Maupay are Leandro Trossard (£5.7m) and Alexis Mac Allister (£5.3m), with Yves Bissouma (£4.5m) and Pascal Groß (£5.8m) in midfield.
Joel Veltman (£4.3m) and Solly March (£5.0m) are selected at wing-back. Ben White (£4.4m) moves back into defence, with Lewis Dunk (£4.8m) and Andy Webster (£4.4m).
Robert Sanchez (£4.4m) is Brighton’s number one.
Ivan Cavaleiro (£4.3m) continues in a false-nine role for Scott Parker’s Fulham side.
Either side of Cavaleiro will be Ademola Lookman (£5.0m), Bobby Decordova-Reid (£5.3m) and Ruben Loftus-Cheek (£5.9m).
Frank Zambo Anguissa (£4.5m) and Harrison Reed (£4.4m) start in midfield for the Cottagers.
Ola Aina, Tosin Adarabioyo, Joachim Andersen and Kenny Tete start in defence. Summer signing Alphonse Areola (£4.5m) is in goal.
Man Utd XI: De Gea; Wan Bissaka, Maguire, Tuanzebe, Telles; Matic, Pogba; Rashford, Fernandes, Greenwood; Martial
Sheff Utd XI: Ramsdale; Basham, Ampadu, Jagielka; Baldock, Bryan, Norwood, Fleck, Lundstram; McGoldrick, Sharp
Leicester XI: Schmeichel; Justin, Fofana, Evans, Castagne; Ndidi, Tielemans; Barnes, Maddison, Albrighton, Perez
Everton XI: Pickford; Holgate, Mina, Keane, Godfrey, Digne; Rodriguez, Gomes, Davies; Richarlison, Calvert-Lewin
Brighton XI: Sanchez; Dunk, Webster, White; Bissouma, Gross, March, Veltman; Mc Allister, Trossard, Maupay
Fulham XI: Areola; Tete, Andersen, Adarabioyo, Aina; Reed, Anguissa; Decordova-Reid, Loftus-Cheek, Lookman; Cavaleiro
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