The penultimate match of Gameweek 28 sees third played fifth in the race for UEFA Champions League qualification.
Kick-off at Old Trafford is at 19:15 GMT.
The most-captained player of Gameweek 28, Bruno Fernandes, features in this clash.
Those Fantasy managers who handed the armband to – or perhaps vice-captained, after yesterday’s Manchester City no-shows – the Portuguese midfielder have a chance to steal a march on their rivals following blanks for the likes of Harry Kane and Son Heung-min in the earlier kick-off.
Ole Gunnar Solskjaer has made just the one change from the United side that triumphed in the Manchester derby.
It’s an enforced one at that, with Mason Greenwood in for the injured Anthony Martial up top.
Martial and Edinson Cavani aren’t involved in the matchday squad and neither is David de Gea, whose spell in quarantine will end after today’s game.
Marcus Rashford is fit to feature, however.
David Moyes has made three alterations from the side that beat Leeds United 2-0 on Monday.
Mark Noble makes his first competitive start since West Ham last played at Old Trafford in the FA Cup at the beginning of February.
Jarrod Bowen and Ben Johnson also come into the side.
Said Benrahma is benched, Pablo Fornals misses out with a minor muscle strain and Jesse Lingard is ineligible to feature against his parent club.
Manchester United XI: Henderson, Wan-Bissaka, Lindelof, Maguire, Shaw, Fred, McTominay, Greenwood, Fernandes, James, Rashford.
West Ham United XI: Fabianski, Coufal, Dawson, Diop, Cresswell, Rice, Soucek, Johnson, Noble, Bowen, Antonio.
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